Table 4.

Etiology and treatment of hyponatremia for patients with initial serum sodium ≥115 mEq/L who experienced osmotic demyelination syndrome

ReferenceEtiology of HyponatremiaTreatment of Hyponatremia
Hu et al. (23)Not mentioned by authorsNS at 1 L over 24 h
Pradhan et al. (17)Not mentioned by authors, presumably from low solute intakeNS and salt tablets
Macmillan et al. (4)Not mentioned by authorsNot mentioned by the authors
Pradhan et al. (17)Salt restriction, persistent vomitingNS, salt tablets, discontinuation of thiazide diuretic and enalapril
Zunga et al. (16)Not mentioned by authors, presumably from viral gastroenteritisOnly mentions “supportive treatment” without specifics
Orakzai et al. (38)Not mentioned by authorsNo specific therapy given
Jahan et al. (39)Not mentioned by authors, presumably from nonbloody diarrheaFree water restriction and “gentle” intravenous fluid repletion with NS
Davenport et al. (21)SIAD secondary to pneumoniaNS
Shah et al. (3)Not mentioned by authorsSalt tablets and NS
  • NS, 0.9% sodium chloride; SIAD, syndrome of inappropriate antidiuresis.