Table 1.

Biomarker assays measuring specific fragments of extracellular matrix proteins

BiomarkerDescriptionSerumUrineReference in which Procedure Is Described
Formation biomarkers
 PRO-C3N-terminal pro-peptide of collagen type IIIxx(36)
 PRO-C6C-terminal of collagen type VI and endotrophinxx(37)
Degradation biomarkers
 C3MMMP-9 mediated degradation of collagen type IIIx(21,38)
  • PRO-C3, biomarker of interstitial collagen type III; PRO-C6, biomarker of interstitial collagen type VI; C3M, biomarker of collagen type III.