Table 2.

Associations of baseline age and frailty with postdialysis recovery time among adults new to hemodialysis

Unadjusted AssociationsAdjusted Associations
ModelIRR (95% Confidence Interval)P ValueIRR (95% Confidence Interval)P Value
Demographic factors and frailtya
 Age ≤65 versus >65 yr2.18 (1.36 to 3.47)0.0012.36 (1.44 to 3.85)0.001
 Obese versus nonobese1.35 (0.79 to 2.29)0.301.76 (1.16 to 2.68)0.008
 Prevalent cerebrovascular disease1.79 (0.99 to 3.23)0.052.03 (1.21 to 3.43)0.007
 Frailty status
  NonfrailReferenceReference
  Intermediately frail1.46 (0.85 to 2.51)0.202.56 (1.45 to 4.52)0.001
  Frail1.06 (0.65 to 1.72)0.801.72 (1.03 to 2.89)0.04
Age stratified by frailty (score ≥2)b
 Among nonfrail (N=58)
  Age ≤65 versus >65 yr2.74 (0.96 to 7.89)0.061.18 (0.41 to 3.39)0.81
 Among frail (N=227)
  Age ≤65 versus >65 yr2.07 (1.23 to 3.49)0.0062.55 (1.46 to 4.43)0.001
  • a The model was also adjusted for sex, race, smoking status, diabetes mellitus, coronary artery disease, congestive heart failure, and mean interdialytic weight gain. Nonfrail was defined as a score of zero or one, intermediately frail was defined as a score of two, and frailty was defined as a score of three or higher.

  • b Frailty was defined as a score of greater than or equal to two, which includes intermediately frail and frail. Models were adjusted for sex, race, obesity, and cerebrovascular disease.

  • IRR, incidence rate ratio.