Table 1.

Characteristics of 1139 patients identified with first-time hospital-recorded nephrotic syndrome in the Danish National Patient Registry, and of 5268 patients with first-time recorded nephrotic proteinuria and hypoalbuminemia identified in Danish Laboratory information systems during 2004–2018

CharacteristicPatients with Hospital-Recorded NSPatients with Nephrotic Proteinuria and Hypoalbuminemia
Overall, n (%)1139 (100)5268 (100)
Male sex, n (%)682 (60)3355 (64)
Age in years, median (IQR)60 (45–73)63 (50–72)
By age group, n (%)
 18–49 yr361 (32)1329 (25)
 50–64 yr310 (27)1646 (31)
 ≥65 yr468 (41)2293 (44)
By period, n (%)
 2004–2006127 (11)414 (8)
 2007–2009124 (11)316 (6)
 2010–2012166 (15)550 (10)
 2013–2015168 (15)947 (18)
 2016–2018a554 (49)3041 (58)
Hospital-recorded kidney disease during 10 yr before index date, n (%)
 GN (excluding nephrotic syndrome)109 (10)538 (10)
 Renal tubulointerstitial diseases41 (4)391 (7)
 AKI and or CKD66 (15)1930 (37)
 Cystic kidney disease<5139 (3)
 Hypertension with nephropathy14 (1)155 (3)
 Diabetic nephropathy55 (5)750 (14)
Hospital-recorded comorbidity during 10 yr before index date, n (%)
 Diabetes206 (18)2032 (39)
 Chronic liver disease29 (3)163 (3)
 Chronic pulmonary disease114 (10)580 (11)
 Connective tissue disease67 (6)402 (8)
 Congestive heart failure72 (6)458 (9)
 Thromboembolic disease192 (17)1328 (25)
 Nonhematologic cancer (excluding nonmelanoma skin cancer)89 (8)485 (9)
 Hematologic cancer42 (4)149 (3)
Filled prescriptions within 365 d before index date, n (%)
 Antidiabetics203 (18)2024 (38)
 Anticoagulants370 (32)2289 (43)
 Thiazides/diuretics364 (32)1483 (28)
β-Blockers321 (28)2121 (40)
 Calcium channel blockers346 (30)2527 (48)
 ACE-inhibitors369 (32)1957 (37)
 Angiotensin II receptor antagonists261 (23)1736 (33)
 Other antihypertensives29 (3)462 (9)
 Statins412 (36)2486 (47)
 Glucocorticoids146 (13)593 (11)
 Immunosuppressants22 (2)105 (2)
Kidney transplant recipient before index date, n (%)16 (1)337 (6)
Kidney biopsy recorded from 6 months before to 6 months after index date, n (%)696 (61)1771 (34)
Any eGFR test before index date, n (%)b1087 (95)5208 (99)
Days since most recent eGFR test, median (IQR)b−7 (−20 to −2)−15 (−54 to −3)
Most recent eGFR ml/min per 1.73 m2, median (IQR)b61 (34–87)35 (17–65)
  • Any percentage in the table is a column percentage. NS, nephrotic syndrome; IQR, interquartile range; ACE, angiotensin-converting enzyme.

  • a During 2004–2015, only patients from Central Denmark Region and North Denmark Region were included, whereas patients from all Danish regions were included during 2016–2018.

  • b eGFR computed from plasma creatinine tests using the Chronic Kidney Disease Epidemiology Collaboration formula.