Table 2.

Taxonomic differences between IgAN and healthy groups

SampleHigh in GroupPhylumClassOrderFamilyGenusSpecies
BloodIgANActinobacteriaActinobacteriaCoriobacterialesCoriobacteriaceaeCollinsella1
ActinobacteriaCoriobacteriiaEggerthellalesEggerthellaceaeUnknown1
ActinobacteriaActinobacteriaActinomycetalesMicrococcaceaeRothia1a
BacteroidetesBacteroidiaBacteroidalesTannerellaceaeParabacteroides1
BacteroidetesBacteroidiaChitinophagalesSaprospiraceaeUnknown1a
ProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella1
FirmicutesClostridiaClostridialesLachnospiraceaeMultiaffiliation1a
FirmicutesClostridiaClostridialesLachnospiraceaeCoprococcus1a
FirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus-11a
HealthyProteobacteriaGammaproteobacteriaBetaproteobacterialesBurkholderiaceaeDelftia1
StoolIgANBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides13
FirmicutesClostridiaClostridialesLachnospiraceaeLachnoclostridium2
FirmicutesClostridiaClostridialesLachnospiraceaeHungatella1
FirmicutesClostridiaClostridialesLachnospiraceaeUnknown1
FirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium1
FirmicutesClostridiaClostridialesRuminococcaceaeUnknown1
ProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia-Shigella1
HealthyBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides2
BacteroidetesBacteroidiaBacteroidalesRikenellaceaeAlistipes2
BacteroidetesBacteroidiaBacteroidalesTannerellaceaeParabacteroides1
BacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella 93
BacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella 21
BacteroidetesBacteroidiaBacteroidalesPrevotellaceaeParaprevotella1
FirmicutesClostridiaClostridialesLachnospiraceaeCAG-561
FirmicutesClostridiaClostridialesRuminococcaceaeNK4A214 group1
FirmicutesClostridiaClostridialesLachnospiraceaeNK4A1361
FirmicutesClostridiaClostridialesLachnospiraceaeLachnoclostridium1
FirmicutesClostridiaClostridialesRuminococcaceaeUCG-0021
FirmicutesClostridiaClostridialesLachnospiraceaeMultiaffiliation/ unknown5
FirmicutesNegativicutesSelenomonadalesVeillonellaceaeAllisonella1
  • Taxonomic differences generated using the linear discriminant analysis effect size (LEfSe) algorithm representing statistical and biologic differences between groups. Numbers in the species column indicate number of different species between groups. Exact species difficult to identify due to clustering and multiple affiliations of organisms. IgAN, IgA nephropathy.

  • a Differences lost after excluding three outliers.