Table 5.

Blood and stool microbiota correlations with clinical parameters of IgA nephropathy

Clinical VariableTaxonomic LevelBloodStool
Positive CorrelationNegative CorrelationPositive CorrelationNegative Correlation
Urine albumin-creatinine ratioPhylumBacteroidetesBacteroidetes
ClassClostridia
OrderLegionellalesBacteroidales, EnterobacterialesClostridiales
FamilyLegionellaceae, StaphylococcaceaeBacteroidaceae, EnterobacteriaceaeChristensenellaceae, Lachnospiraceae
GenusLegionellaBacteroidesCAG-56 (Lachnospiraceae)
StaphylococcusEscherichia-ShigellaChristensenellaceae R7 group, Cutibacterium, Prevotella 9, Ruminococcaceae NK4A214 group, Ruminococcaceae UCG005, Eubacterium eligens group
GFR ≤60 ml/min (n=11)PhylumCyanobacteriaaProteobacteriaa
ClassCoriobacteriia,a OxyphotobacteriaaBacillia
OrderBifidobacteriales,a Chloroplast,a CoriobacterialesaNegativicutes,a Selenomonadalesa
FamilyBifidobacteriaceaeaVeillonellaceaea
GenusArhtrobacteraDTU089 (family Ruminococcaceae),a Dialistera
C-reactive protein (mg/L)PhylumActinobacteria
ClassCoriobacteriiaActinobacteria
OrderCoriobacterialesCaulobacteralesBifidobacteriales
FamilyCaulobacteriaceaeBacteroidaceae, BifidobacteriaceaeMarinifilaceae
GenusBacteroides, BifidobacteriumCAG-56 (Lachnospiraceae)
MEST-C score (n=16)bClassGammaproteobacteria
FamilyRikenellaceaea
GenusAlistepes,a Anaerostipesa
Serum IgA level (mg/dl) (n=12)bOrderBacteroidalesa
FamilyBacteroidaceaeaBacteroidaceaea
GenusBacteroides,a Butyricimonasa
Serum albumin (g/dl)GenusRuminiclostridium 6, Ruminococcus 2
White blood cell count in bloodFamilyRhizobiaceae
GenusCAG-56 (Lachnospiraceae), Dorea, Ruminococcaceae NK4A214 group, Eubacterium eligens group
16S rDNA (copies/μl blood)OrderMicrococcalesBifidobacteriales
FamilyBifidobacteriacaeae
  • MEST-C, Mesangial cellularity, Endocapillary cellularity, Segmental sclerosis, Tubular atrophy, Crescent; rDNA, ribosomal DNA.

  • a Strong correlation with correlation coefficient ≥0.6, others without a footnote symbol (a) have a correlation coefficient <0.6.

  • b Missing values and historical measures that may have changed with time (interpret with caution).