Table 1.

Baseline characteristics of the study groups

VariableIgAN (n=20)Healthy (n=20)P Value
Age (yr), median (IQR)37 (34–50)38 (30–55)0.98
Male, n (%)9 (45)9 (45)1.0
White, n (%)13 (65)13 (65)1.0
Body mass index (kg/m2), mean±SD29.3±5.826.2±4.40.06
White blood cell (per μl), mean±SD7.5±2.06.3±1.50.04
Serum albumin (g/dl), median (IQR)4.2 (3.9–4.4)4.4 (4.2–4.7)0.03
Urine microalbumin-creatinine ratio (mg/g), median (IQR)545.6 (134.8–1168.6)2.3 (0.7–5.9)<0.01
CRP (mg/L), median (IQR)2.6 (1.0–6.5)1.6 (0.7–3.0)0.13
eGFR (ml/min), median (IQR)55 (27.5–88)100 (81–110)<0.01
Allergy history, n (%)a10 (50)6 (30)0.19
Perceived stress score, mean±SDb15.2±6.26.7±3.7<0.01
16S DNA (copies/μl blood), median (IQR)7410 (6370–8695)6030 (4796–7505)0.04
  • Data expressed as median (IQR), mean±SD, or n (%) as appropriate. Significant differences between groups detected in white blood cell count, serum albumin, urine microalbumin/creatinine ratio, eGFR, perceived stress score, and 16S DNA copies. eGFR determined using Chronic Kidney Disease Epidemiology Collaboration equation. IgAN, IgA nephropathy; IQR, interquartile range; CRP, C-reactive protein.

  • a Reported or documented allergy to food product or drugs.

  • b Two patients with IgAN and one healthy subject excluded due to language or understanding barrier.