Table 2.

Hazard ratios for primary end points per SD increase in GRS and comparing the top and bottom GRS quartiles

Outcome/GRSAfrican AncestryEuropean Ancestry
ContinuousQuartileContinuousQuartile
HR (95% CI)aP ValueHR (95% CI)bP ValueHR (95% CI)aP ValueHR (95% CI)bP Value
CVD eventc
 SBP1.10 (1.01 to 1.20)0.031.21 (0.95 to 1.53)0.121.15 (1.04 to 1.27)0.0061.41 (1.06 to 1.88)0.02
 DBP1.09 (1.00 to 1.18)0.051.15 (0.90 to 1.47)0.251.09 (0.99 to 1.20)0.091.18 (0.89 to 1.56)0.25
 PP1.06 (0.97 to 1.15)0.221.18 (0.92 to 1.52)0.181.11 (1.01 to 1.23)0.041.33 (1.00 to 1.76)0.05
CKD progression eventd
 SBP1.00 (0.92 to 1.08)0.990.93 (0.75 to 1.16)0.551.07 (0.97 to 1.18)0.191.06 (0.80 to 1.40)0.67
 DBP1.03 (0.95 to 1.11)0.461.12 (0.90 to 1.40)0.311.00 (0.90 to 1.10)0.930.96 (0.74 to 1.25)0.76
 PP0.97 (0.89 to 1.05)0.400.91 (0.73 to 1.13)0.401.07 (0.97 to 1.19)0.171.18 (0.90 to 1.55)0.24
  • GRS, genetic risk score; HR, hazard ratio; CVD, cardiovascular disease, SBP, systolic BP; DBP, diastolic BP; PP, pulse pressure; CRIC, Chronic Renal Insufficiency Cohort.

  • a Results of Cox proportional hazards models, per SD increase in BP GRS, adjusted for age, sex, CRIC study site, and ancestry principal components.

  • b Results of Cox proportional hazards models, comparing top quartile BP GRS with bottom quartile BP GRS, adjusted for age, sex, CRIC study site, and ancestry principal components.

  • c Composite of myocardial infarction, stroke, and congestive heart failure.

  • d Halving of eGFR or ESKD.