Table 6.

Association of post-transplant diabetes mellitus with adverse graft outcomes

ExposureDeath-censored Graft FailureAll-cause Graft FailureAll-cause Mortality
n (%)Event rate per 1000 Person-yearsUnadjusted Hazard Ratio (95% Confidence Interval)Adjusteda Hazard Ratio (95% Confidence Interval)n (%)Event rate per 1000 Person-yearsUnadjusted Hazard Ratio (95% Confidence Interval)Adjusteda Hazard Ratio (95% Confidence Interval)n (%)Event rate per 1000 Person-yearsUnadjusted Hazard Ratio (95% Confidence Interval)Adjusteda Hazard Ratio (95% Confidence Interval)
ANo PTDM (n=446)93 (21)37 (30, 46)1 (ref)1 (ref)145 (33%)58 (49, 68)1 (ref)1 (ref)70 (16%)28 (22, 35)1 (ref)1 (ref)
PTDM (n=186)25 (21)32 (21, 47)0.92
(0.58 to 1.48)
0.85
(0.53 to 1.37)
54 (28%)67 (51, 88)1.23
(0.89 to 1.70)
1.10
(0.78 to 1.55)
34 (18%)43 (31, 60)1.56
(1.03 to 2.38)
1.31
(0.84 to 2.05)
BNo PTDM (n=446)93 (21)37 (30, 46)1 (ref)1 (ref)145 (33%)58 (49, 68)1 (ref)1 (ref)70 (16%)28 (22, 35)1 (ref)1 (ref)
Early-onset PTDMb(n=117)14 (12)23 (14, 39)0.70
(0.40 to 1.23)
0.56
(0.31 to 1.04)
32 (27%)53 (37, 74)0.98
(0.66 to 1.44)
0.85
(0.57 to 1.28)
23 (20%)38 (25, 57)1.39
(0.86 to 2.24)
1.16
(0.70 to 1.91)
Late-onset PTDMb (n=69)11 (16)62 (34, 112)1.86
(0.97 to 3.59)
2.14
(1.08 to 4.21)
21 (30%)118 (77, 182)2.09
(1.29 to 3.37)
2.07
(1.25 to 3.44)
11 (16%)62 (34, 112)2.20
(1.13 to 4.27)
1.91
(0.93 to 3.92)
  • PTDM, post-transplant diabetes mellitus; KDPI, kidney donor profile index.

  • a Adjusted models include donor KDPI, cold ischemia time and the following recipient variables: age (years), Black race, sex, previous kidney transplant, number of human leukocyte antigen mismatches, panel reactiveantibody (%), body mass index (kg/m2), preemptive transplant, and transplant center.

  • b Early diabetes is new onset diabetes within 1 year post-transplant, whereas late diabetes is new onset diabetes after 1 year post-transplant.