Table 2.

ADPKD severity markers and distribution of urinary biomarkers

Analytes N Mean±SDMedian (range)
Creatinine (µM)951086.5±844.0818.2 (141.8–3771.1)
Osmolality (mmol/kg)95399.0±219.7374 (91–1098)
Protein (mg/dl) 951.65±1.481.19 (0.09–7.87)
 Protein/creatinine ratio950.0018±0.00150.0014 (0.0001–0.0118)
 Protein/osmolality ratio950.0045±0.00460.0034 (0.0007–0.0366)
Lactate (µM) 9513.3±12.310.4 (0.4–67.9)
 Lactate/creatinine ratio950.018±0.0220.011 (0.001–0.133)
 Lactate/osmolality ratio950.039±0.0380.029 (0.002–0.177)
Pyruvate (µM) 959.32±4.858.56 (2.04–27.17)
 Pyruvate/creatinine ratio950.013±0.0110.012 (0.001–0.071)
 Pyruvate/osmolality ratio950.029±0.0160.025 (0.004–0.096)
Lactate/pyruvate ratio951.64±1.801.19 (0.04–11.10)
Succinate (µM) a 9441.8±24.536.6 (8.8–128.9)
 Succinate/creatinine ratio940.062±0.0600.042 (0.008–0.376)
 Succinate/osmolality ratio940.131±0.0990.103 (0.031–0.656)
cAMP (µM) 951.67±0.771.57 (0.02–3.99)
 cAMP/creatinine ratio950.0022±0.00130.0017 (0.0000–0.0071)
 cAMP/osmolality ratio950.0048±0.00240.0043 (0.0001–0.0138)
PKM2 (pg/ml) 957819±64355795 (6–27,542)
 PKM2/creatinine ratio958.39±7.336.47 (0.01–43.30)
 PKM2/osmolality ratio9520.47±18.3315.87 (0.01–134.50)
PDK1 (pg/ml) 95178.0±97.8152.2 (120.8–851.3)
 PDK1/creatinine ratio950.271±0.2100.208 (0.043–1.177)
 PDK1/osmolality ratio950.621±0.5520.474 (0.149–4.627)
LDHA (pg/ml) a 943230±44161661 (13–28,763)
 LDHA/creatinine ratio943.26±3.422.22 (0.03–24.21)
 LDHA/osmolality ratio948.23±9.555.16 (0.06–55.31)
  • ADPKD, autosomal dominant polycystic kidney disease; PKM2, pyruvate kinase M2; PDK1, pyruvate dehydrogenase kinase 1; LDHA, lactate dehydrogenase A.

  • a Succinate and LDHA values were below the lower limit of detection for one patient each.