Table 1.

Results in stenosed mice at a glance

ParametersSox6-WT MiceSox6-KO Mice
BPIncreased BPProtected against high BP
Prorenin and renin expressionIncreased in stenosed kidneyInhibited in both stenosed and contralateral kidneys
Repressed in contralateral kidney
JG cell recruitmentIncreased in stenosed kidneyInhibited in both stenosed and contralateral kidneys
No JG cell recruitment in contralateral kidneys
Colocalization of renin and Sox6 expressionIncreased in stenosed kidneyInhibited in both stenosed and contralateral kidneys
No colocalization in contralateral kidneys
NGAL expressionIncreased in stenosed kidneyInhibited in stenosed kidney
Decreased expression in contralateral kidneyDecreased expression in contralateral kidney
Creatinine clearanceDiminishedPreserved
  • WT, wild type; KO, knockout; JG, juxtaglomerular; NGAL, neutrophil gelatinase-associated lipocalin.