Table 2.

The association of clinical characteristics with total glomerular number per kidney and single-nephron parameters

Clinical VariablesNon-globally Sclerotic Glomeruli (Number Per Kidney)Globally Sclerotic Glomeruli (Number Per Kidney)Total Glomeruli (Number Per Kidney)Mean Glomerular Volume (×106 μm3)Single-nephron GFR (nl/min)Single-nephron Urinary Protein Excretion (μg/d)
Estimate P valueEstimate P valueEstimate P valueEstimate P valueEstimate P valueEstimate P value
Univariable
 CKD categorya −196,284<0.00150,918<0.001−145,366<0.0010.327<0.0012.1360.211.406<0.001
 Hypertension−154,5440.02−56510.88−160,1950.020.4030.0610.5070.0471.432<0.001
 UPE ≥1 g/d−190,543<0.00156,1990.053−134,3450.020.3370.048−2.0340.632.949<0.001
Multivariable b
 CKD categorya −172,720<0.00149,712<0.001−123,007<0.0010.311<0.0012.2900.291.225<0.001
 Hypertension−93,5750.08−35,8910.33−129,4660.0460.1860.3611.4200.040.6000.15
 UPE ≥1 g/d20,9440.66−12,6050.7083380.88−0.2650.14−9.3010.061.940<0.001
  • BSA, body surface area; CKD, chronic kidney disease; GFR, glomerular filtration rate; UPE, urinary protein excretion.

  • a Five categories of CKD stage were defined: eGFR levels ≥90, 60–89, 45–59, 30–44 and<30 ml/min per 1.73 m2, respectively.

  • b Adjusted for age, sex, and BSA in addition to CKD stage, hypertension, and UPE.