Table 1.

Demographics, clinical characteristics, and outcomes associated with no, functional, and persistent AKI on the basis of creatinine corrected for fluid overload

CharacteristicNo AKI (N=526)Functional AKI (N=107)Persistent AKI (N=83)
Sex (female)282 (53)67 (63)45 (54)
Age (yr)8.4 (2.2–13.9)9.1 (3.7–15.4)11.5 (2.8–16.7)
Weight (kg)24.6 (12.3–45.9)27 (13.4–59.3)31.5 (13.5–55)
History of transplanta 60 (11)14 (13)20 (24)b , c
Sepsis69 (13)20 (19)22 (27)b , c
PRISM-III5 (2–10)10 (3.5–17)d 12 (5–17)b , c
Baseline creatinine0.37 (0.26–0.5)0.38 (0.26–0.53)0.39 (0.27–0.52)
Baseline eGFR126 (126–140)126 (126–140)133 (126–140)
Calculated baseline creatinine286 (55)57 (54)39 (47)
Day 0 creatinine0.41 (0.28–0.58)0.87 (0.65–1.23)0.89 (0.51–1.85)
Day 1 creatinine0.39 (0.28–0.57)0.68 (0.47–0.87)1.09 (0.65–1.74)
KeGFR on day 1122.7 (105–145)91.2 (81.4–114.5)d 58.5 (28.6–80.3)b , c
eGFR on day 1122.5 (104.9–144.6)86.7 (72.9–103.7)d 51.6 (30.8–72.7)b , c
Day 3 creatinine0.36 (0.26–0.52)0.44 (0.27–0.61)1.21 (0.89–2.52)b , c
KeGFR on day 3128 (107.1–155.1)105.4 (90.5–132)45.8 (17.6–59.7)b , c
eGFR on day 3129.1 (106.8–158.6)108 (95.7–143.2)44.3 (23.1–58.3)b , c
Need for MV248 (46)53 (50)40 (48)
MV duration (d)5 (2–8)4 (2–7)6 (4–9)
ICU LOS (d)6 (4–11)5 (4–10)7 (4–11)
Mortality35 (7)5 (5)15 (18)b , c
  • All continuous variables are presented as median with interquartile range. Categoric variables are presented as number with percentage. PRISM-III, Pediatric Risk of Mortality III; KeGFR, kinetic eGFR; MV, mechanical ventilation; ICU, intensive care unit; LOS, length of stay.

  • a Includes solid organ or stem cell.

  • b P<0.05 for functional AKI compared with persistent AKI.

  • c P<0.05 for persistent AKI compared with no AKI.

  • d P<0.05 for functional AKI compared with no AKI.