Table 1.

Baseline clinical and biochemical characteristic of the study populationa

CharacteristicCryoglobulin PositiveCryoglobulin NegativeP value
No. of patients2897483
Age, yr62.5±16.061.2±17.90.18
Male sex, no. of patients (%)145 (50%)3397 (45%)0.11
Laboratory parameters
 Hemoglobin (g/dl)10.8±2.211.5±2.4<0.001
 White blood cell (×109/L)7.3±4.58.4±6.80.006
 Platelet (×109/L)221.7±114.3244.8±126.70.003
 Urea (mmol/L)8.5±7.89.5±9.30.05
 Creatinine (µmol/L)134.1±177.5156.2±195.50.05
 eGFR (ml/min per 1.73 m2)81.6±54.482.5±107.40.90
 Total protein (g/L)71.4±15.469.9±11.70.12
 Globulin (g/L)38.9±13.636.2±9.60.002
 Albumin (g/L)32.6±8.333.6±8.60.05
 Bilirubin (µmol/L)15.3±44.115.3±33.90.97
 Alkaline phosphatase (IU/L)89.9±58.596.7±81.10.18
 Alanine aminotransferase (IU/L)40.1±93.641.7±126.70.83
 Aspartate aminotransferase (IU/L)88.7±301.167.9±283.00.46
 Gamma-glutamyl transferase (IU/L)135.4±235.2136.6±195.10.96
 Rheumatoid factor positive, no. of case (%)60 (44.1%)1012 (31%)0.001
 C3 (g/L)0.89±0.441.01±0.36<0.001
 C4 (g/L)0.19±0.160.25±0.12<0.001
 IgA (g/L)3.11±2.133.76±2.890.13
 IgG (g/L)16.44±13.4915.90±8.240.79
 IgM (g/L)6.62±14.012.09±5.810.03
 Urine protein-creatinine ratio3.30±4.132.86±4.030.39
  • a Data expressed as mean±SD.