Table 2.

Clinical data and most relevant acute renal lesions observed by light microscopy, immunostaining, in situ hybridization

Patient StatusGlomeruli Tubulointerstitium Peritubular Capillaries Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Data
Patient IDIschemiaCapillary CongestionEndothelial Cell SwellingAcute Tubular NecrosisTubular vacuolizationCapillaritisCongestionIHCISHDMHTNAKI stageProteinuria mg/g
Severity ExtentTubulesGlomeruli Tubules
COVIDICU3NYNMild>0%–25%Nptc1Y>10%NANANY2333
4YYNMild>0%–25%>0%–25%ptc0YNYYYNN595
6YYNMild26%–50%Nptc1Y<1%NANANY2453
7YNNSevere>50%>0%–25%a,b ptc0Y<1%NANANYRRT353
8NNNSevere>50%Nptc2Y<1%NBdlNNRRT689
10NNNSevere>50%Nptc0Y<1%NNYYRRT317
11NYYMild26%–50%26%–50%a,b ptc0Y<1%BdlBdlNN1230
13NYNMild>0%–25%>0%–25%ptc0YNNANAYY3834
15NYNModerate>50%>0%–25%ptc0NNNNNY2728
16NNNMild>50%Nptc0YNNANAYNN1484
Non-ICU1YYNMild>0%–25%Nptc0Y1%–10%NNYNNNA
2NNNMild>0%–25%Nptc0YNYYYYN303
5NNNMild>0%–25%>0%–25%*ptc0YNNBdlYNN1104
9NYNMild>0%–25%>0%–25%ptc0Y1%–10%BdlBdlYYN268
12YNNMild>0%–25%26%–50%ptc0YNNANAYY26004
14NYNMild26%–50%>0%–25%ptc0N<1%NANANY1579
Control ICUP1NNYMild26%–50%Na ptc0NNNN1654
R1YNNSevere>50%>50%ptc2NNNY3387
R2NNNSevere>50%Na ptc0YNYN22607
R3NNNModerate>50%>0%–25%a ptc0NNYYRRTNA
R4NNNSevere>50%26%–50%ptc0NNNN2NA
  • Capillaritis was scored according to the Banff scoring system (0, <10% cortical PTC containing leukocytes; 1, ≥10% cortical PTC containing 3–4 leukocytes; 2, ≥10% cortical PTC containing 5–10 leukocytes) (41). ID, identification number; IHC, immunohistochemistry; ISH, in situ hybridization; DM, diabetes mellitus; HTN, hypertension; COVID, coronavirus disease; ICU, intensive care unit; N, not detected; Y, detected; NA, not available; PTC, peritubular capillaries; Bdl, borderline.

  • a Patients exposed to IV contrast.

  • b Patients treated by calcineurin inhibitor.