Table 1.

Centers for Disease Control and Prevention criteria for multisystem inflammatory syndrome in children

CDC Criteria for MIS-C
Age <21 yr
Clinical presentation consistent with MIS-C, including all of the following
 Fever
  Documented fever >38.0°C (100.4°F) for ≥24 h or report of subjective fever lasting ≥24 h
 Laboratory evidence of inflammation including, but not limited to, any of the following
  Elevated CRP
  Elevated ESR
  Elevated fibrinogen
  Elevated procalcitonin
  Elevated d -dimer
  Elevated ferritin
  Elevated LDH
  Elevated IL-6 level
  Neutrophilia
  Lymphocytopenia
  Hypoalbuminemia
 Severe illness requiring hospitalization
Multisystem involvement—two or more organ systems involved
  Cardiovascular (e.g., shock, elevated troponin, elevated BNP, abnormal echocardiogram, arrhythmia)
  Respiratory (e.g., pneumonia, ARDS, pulmonary embolism)
  Renal (e.g., AKI, renal failure)
  Neurologic (e.g., seizure, stroke, aseptic meningitis)
  Hematologic (e.g., coagulopathy)
  Gastrointestinal (e.g., elevated liver enzymes, diarrhea, ileus, gastrointestinal bleeding)
  Dermatologic (e.g., erythroderma, mucositis, other rash)
 No alternative plausible diagnoses
 Recent or current SARS-CoV-2 infection or exposure
  • MIS-C, multisystem inflammatory syndrome in children; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; LDH, lactate dehydrogenase; BNP, B-type natriuretic peptide; ARDS, acute respiratory distress syndrome; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.