Table 3.

Clinical and treatment characteristics of patients on hemodialysis with and without an undetected severe acute respiratory syndrome coronavirus 2 infection identified in the subsequent ≥3 d

VariableUnaffected Patients, Mean±SD; NCoronavirus Disease 2019+ Patients, Mean±SD; N
Number of patients on HD29,32411,166
Pre-HD sitting SBP (mm Hg)a148.31±22.83; 29,324146.03±23.03; 11,166
Change in pre-HD sitting SBP (mm Hg)b−0.40±15.78; 29,324−1.95±16.72; 11,166
Pre-HD sitting DBP (mm Hg)a76.87±13.86; 29,32275.44±13.58; 11,166
Change in pre-HD sitting DBP (mm Hg)b−0.32±9.03; 29,322−0.88±9.48; 11,166
Pre-HD weight (kg)a85.71±24.51; 29,32385.09±24.51; 11,165
Change in pre-HD weight (kg)b−0.17±2.24; 29,323−0.66±2.73; 11,165
Pre-HD body temperature (°F)a97.56±0.61; 29,32497.76±0.66; 11,166
Change in pre-HD body temperature (°F)b0.07±0.56; 29,3240.22±0.65; 11,166
Post-HD sitting SBP (mm Hg)a140.40±21.60; 29,321144.44±21.62; 11,166
Change in post-HD sitting SBP (mm Hg)b0.43±14.98; 29,3201.55±15.74; 11,166
Post-HD sitting DBP (mm Hg)a73.91±12.58; 29,31973.56±12.33; 11,166
Change in post-HD sitting DBP (mm Hg)b0.15±8.49; 29,3180.41±8.79; 11,166
Post-HD body temperature (°F)a97.58±0.56; 29,31897.70±0.62; 11,166
Change in post-HD body temperature (°F)b0.03±0.50; 29,3170.14±0.57; 11,165
Pre-HD respirations per mina17.64±1.16; 29,32417.72±1.15; 11,166
Change in pre-HD respirations per minb−0.001±0.97; 29,3240.01±1.02; 11,166
Pre-HD pulse (BPM)a79.00±12.11; 29,32479.02±11.90; 11,166
Change in pre-HD pulse (BPM)b0.11±7.26; 29,3241.06±7.56, 11,166
Post-HD respirations per mina17.56±1.15; 29,32017.65±1.13; 11,165
Change in post-HD respirations per minb−0.007±0.95; 29,3190.0004±0.99; 11,165
Post-HD pulse (BPM)a75.80±11.23; 29,32177.23±11.16; 11,166
Change in post-HD pulse (BPM)b−0.32±7.16; 29,3201.30±7.87; 11,166
IDWG (kg)a2.24±1.21; 29,0831.95±1.29; 11,039
Change in IDWG (kg)b0.01±0.90; 29,004−0.26±1.09; 10,991
Post-HD weight loss (kg)a−2.26±1.07; 29,317−2.06±1.07; 11,160
Change in post-HD weight loss (kg)b−0.01±0.68; 29,3160.18±0.77; 11,159
Post-HD body temperature changea0.01±0.66; 29,318−0.06±0.70; 11,165
Change in post-HD body temperature changeb−0.04±0.66; 29,317−0.07±0.71; 11,165
Post-HD respirations per min changea−0.08±0.97; 29,320−0.07±0.97; 11,165
Change in post-HD respirations per min changeb−0.01±1.04; 29,319−0.01±1.07; 11,165
Post-HD pulse change (BPM)a−3.20±8.86; 29,321−1.79±8.77; 11,166
Change in post-HD pulse change (BPM)b−0.43±7.75; 29,3200.24±8.06; 11,166
% HD treatments with nasal oxygen administereda5.23±18.52; 29,3245.67±19.16; 11,166
Change in % HD treatments with nasal oxygen administeredb0.37±13.40; 29,3240.72±14.12; 11,166
  • All variables were included in the ML prediction model to classify the risk of an individual HD patient having a SARS-CoV-2 infection being identified in the following ≥3 d. (100°F−32) ×5/9=37.8°C. HD, hemodialysis; SBP, systolic blood pressure; DBP, diastolic blood pressure; BPM, beats per minute; IDWG, interdialytic weight gain; post-HD weight loss, post-HD minus pre-HD weight (kg); ML, machine learning; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

  • a Mean values of HD treatment variables 1–7 d before the prediction date (i.e., 3 d before suspicion of SARS-CoV-2 infection in standard clinical practice).

  • b Mean values of the difference in HD treatment variables 31–60 d to 1–7 d before the prediction date.