Table 2.

Association between demographic factors and risk of discontinuation in the overall cohort and risk factors for early discontinuation

VariableOverall Cohort Hazard Ratio (95% Confidence Interval)Early Discontinuationa Hazard Ratio (95% Confidence Interval)
Treatment modality
 PD only (versus HD only as reference)0.45 (0.42 to 0.49)0.37 (0.33 to 0.41)
 HD to PD (versus HD only as reference)1.02 (0.97 to 1.07)0.74 (0.67 to 0.82)
 PD to HD (versus PD only as reference)2.73 (2.46 to 3.03)3.22 (2.72 to 3.81)
Age at dialysis onset (yr)
 18–29ReferenceReference
 30–644.11 (3.25 to 5.20)3.68 (2.55 to 5.32)
 ≥6515.85 (12.54 to 20.03)14.63 (10.15 to 21.10)
Sex
 MaleReferenceReference
 Female1.16 (1.13 to 1.19)1.17 (1.13 to 1.21)
Race/Ethnicity
 Non-Hispanic WhiteReferenceReference
 Non-Hispanic Black0.32 (0.31 to 0.33)0.31 (0.30 to 0.33)
 Hispanic0.29 (0.27 to 0.30)0.27 (0.25 to 0.29)
 Other0.30 (0.28 to 0.32)0.27 (0.24 to 0.31)
Region
 WestReferenceReference
 Midwest1.16 (1.12 to 1.21)1.12 (1.06 to 1.17)
 South1.04 (1.01 to 1.08)1.03 (0.98 to 1.08)
 Northeast0.77 (0.74 to 0.80)0.71 (0.67 to 0.75)
Median income in zip code0.97 (0.97 to 0.98)0.97 (0.96 to 0.98)
Primary cause of renal failure
 Diabetes mellitusReferenceReference
 Hypertension1.04 (1.01 to 1.08)1.12 (1.07 to 1.17)
 GN0.81 (0.77 to 0.86)0.89 (0.82 to 0.97)
 Cystic kidney disease0.67 (0.60 to 0.75)0.52 (0.43 to 0.63)
 Other/Unknown cause1.02 (0.99 to 1.07)1.35 (1.28 to 1.42)
Yr of dialysis initiation
 2005–2008ReferenceReference
 2009–20121.22 (1.18 to 1.25)1.16 (1.12 to 1.21)
 2013–20151.61 (1.56 to 1.66)1.55 (1.49 to 1.62)
Uninsured (versus Insured)0.57 (0.53 to 0.62)0.53 (0.46 to 0.61)
Comorbidity (versus without condition)
 Stroke1.42 (1.37 to 1.47)1.46 (1.39 to 1.53)
 Diabetes mellitus1.01 (0.97 to 1.04)0.96 (0.92 to 1.00)
 Hypertension0.92 (0.89 to 0.95)0.83 (0.80 to 0.87)
 Heart failure1.20 (1.17 to 1.23)1.28 (1.23 to 1.32)
 Coronary artery disease1.09 (1.06 to 1.12)1.06 (1.02 to 1.11)
 Peripheral vascular disease1.20 (1.16 to 1.24)1.22 (1.16 to 1.27)
 Malignancy1.42 (1.37 to 1.48)1.49 (1.42 to 1.56)
 Smoking1.13 (1.07 to 1.18)1.05 (0.98 to 1.13)
 Drug dependence1.03 (0.88 to 1.20)1.31 (1.06 to 1.62)
  • PD, peritoneal dialysis; HD, hemodialysis.

  • a Analysis limited to 1.9 yr of follow-up (median time to discontinuation of dialysis for overall cohort).