Table 3.

Crosstabulations: Association of key clinical predictors assessed by chart review and biopsy findings in the subcohort (N=79)

VariableSensitivitySpecificityPositive Predictive ValueNegative Predictive ValueOdds Ratio (95% Confidence Interval)P Value
Retinopathy0.860.810.810.8727.1 (6.82 to 107.77)<0.001
AKI0.170.390.180.370.1 (0.04 to 0.38)<0.001
Rapid decline of eGFR0.340.980.920.6522.4 (2.75 to 183.09)0.004
Type 1 DM0.090.910.430.560.9 (0.20 to 4.48)0.94
Type 2 DM0.830.200.450.601.3 (0.39 to 3.90)0.71
Duration of DM <10 yr0.410.460.440.430.6 (0.21 to 1.75)0.36
eGFR<30 ml/min per 1.73 m20.680.250.500.420.7 (0.18 to 2.77)0.63
eGFR (continuous), per 15-ml/min per 1.73 m2 increment1.0 (0.74 to 1.46)0.84
Urine protein <3.5 g/g0.140.760.430.420.5 (0.10 to 2.86)0.47
Urine protein (continuous), per 1-g/g increment1.1 (0.97 to 1.28)0.14
Abnormal serology0.230.590.310.490.4 (0.16 to 1.15)0.09
Hematuria (any)0.450.360.320.500.5 (0.16 to 1.43)0.19
HbA1c<8.0%0.570.350.440.480.7 (0.26 to 2.10)0.56
HbA1c (continuous), per 1.0% increment1.0 (0.81 to 1.29)0.83
  • Crosstabulation analysis of the subgroup of 79 patients looking at sensitivity, specificity, positive predictive value, negative predictive value, odds ratio, and P values for diabetic nephropathy. DM, diabetes mellitus; HbA1c, hemoglobin A1c.