Table 3.

Change in the relative abundance of specific fecal bacteria taxa

TaxaaPbFDRcArmRelative Abundance (%)d
Visit 1Visit 2
Firm: Clostridium0.00030.020Placebo0.115 (0.004–0.901)0.232 (0.038–0.976)
Rifaximin0.218 (0.026–0.634)0.003 (0.001–0.007)
Firm: Turicibacter0.0010.029Placebo0.014 (0.004–0.090)0.097 (0.003–0.416)
Rifaximin0.003 (0.001–0.199)0.000 (0.000–0.002)
Firm: Anaerotruncus0.0040.096Placebo0.307 (0.127–1.190)0.358 (0.199–0.495)
Rifaximin0.306 (0.204–0.389)0.141 (0.090–0.175)
Firm: Streptococcus0.0080.144Placebo0.156 (0.091–0.580)0.384 (0.104–1.183)
Rifaximin0.324 (0.142–1.728)0.229 (0.088–0.451)
Firm: Anaerofustis0.010.145Placebo0.007 (0.004–0.029)0.014 (0.010–0.022)
Rifaximin0.011 (0.006–0.016)0.006 (0.001–0.014)
Firm: Christensenellaceae, other0.010.145Placebo0.426 (0.277–1.666)0.817 (0.182–1.959)
Rifaximin1.812 (0.321–7.799)0.821 (0.103–2.888)
Firm: Family XIII, Incertae sedis, other0.010.145Placebo0.328 (0.207–0.969)0.537 (0.185–0.683)
Rifaximin0.563 (0.308–0.766)0.200 (0.061–0.339)
Firm: Eubacterium0.020.165Placebo0.000 (0.000–0.011)0.000 (0.000–0.010)
Rifaximin0.000 (0.000–0.007)0.000 (0.000–0.000)
Acti: Actinomyces0.030.241Placebo0.023 (0.006–0.041)0.024 (0.016–0.048)
Rifaximin0.036 (0.008–0.104)0.016 (0.005–0.051)
Firm: Peptostreptococcaceae, other0.050.377Placebo0.406 (0.085–2.520)0.814 (0.186–2.316)
Rifaximin1.343 (0.212–3.441)0.041 (0.008–1.453)
  • FDR, false discovery rate; Firm, Firmicutes; Acti, Actinobacteria.

  • a Genus-level taxa differing by treatment arm and time point. Taxa are listed in descending order of relative abundance. Names are prepended with phylum names. Families that could not be classified into individual genera are designated with “other.”

  • b P values for nonparametric test comparing change in relative abundance over time between placebo and rifaximin. Only taxa with P≤0.05 are displayed.

  • c False discovery rate–corrected P values.

  • d Median relative abundances and interquartile ranges of taxa.