Table 1.

Side-by-side characteristics of AlloSure versus Prospera

Limit of detection0.12%0.15%
Claimed sensitivity for TCMRRCV >0.5% (9)100% at 1% (7)
Claimed AUC for all rejection77%87%
Number of SNPs40513,962
Precision (CV)5% and 8% for samples above and below 2% dd-cfDNA, respectively (5)4% (6)
Lowest input material needed3 ng (5)15 ng (6)
Blood tubes needed12
  • TCMR, T cell–mediated rejection; RCV, relative change value; AUC, area under the curve; SNP, single nucleotide polymorphism; CV, change value; dd-cfDNA, donor derived, cell-free DNA.