Table 1.

Summary of protein diversity in large renal tubular extracellular vesicles

LocationCategoryUniProt/Swiss-Prot/GenPept AccessionProtein SymbolScan CountPeptide CountEntrez Gene Name
CytoplasmicEnzymesP19468GSH125260Glutamate-cysteine ligase catalytic subunit
P04764ENOA17139Enolase 1
P07632SODC8109SOD1
Ion channelsP81155VDAC21044Voltage dependent anion channel 2
Q9Z2L0VDAC1622Voltage dependent anion channel 1
KinasesQ4KLZ6TKFC1674Triokinase and FMN cyclase
P16617PGK11040Phosphoglycerate kinase 1
P07379PCKGC830Phosphoenolpyruvate carboxykinase 1
PeptidasesP00758KLK18165Kallikrein 1
P00787CATB12147Cathepsin B
P16675PPGB10125Cathepsin A
PhosphatasesP25113PGAM1836Phosphoglycerate mutase 1
P20611PPAL827Acid phosphatase 2, lysosomal
Q91YE95NT1B8185′-Nucleotidase, cytosolic 1B
TransportersP55054FABP91060Fatty acid binding protein 9
P19511AT5F1359ATP synthase peripheral stalk-membrane subunit b
P10719ATPB1444ATP synthase F1 subunit β
ExtracellularCytokinesP08721OSTP786Secreted phosphoprotein 1
Q9CPT4MYDGF314Myeloid-derived growth factor
P06684CO5412Complement C5
Growth factorsP07522EGF44590EGF
P01015ANGT15189Angiotensinogen
P23785GRN798Granulin precursor
Other proteinsP17475A1AT402659Serpin family A member 1
P05545SPA3K322252Serine protease inhibitor A3K precursor
P27590UROD241724Uromodulin
PeptidasesQ01177PLMN581172Plasminogen
P01026CO378949Complement C3
P06866HPT24401Haptoglobin
TransportersP02770ALBU916,638Albumin
P12346TRFE653405Transferrin
P14046MUG1741583Murinoglobulin 1
Plasma membraneEnzymesP07314GGT121324γ-Glutamyltransferase 1
P97675ENPP31023Ectonucleotide pyrophosphatase/phosphodiesterase 3
Q8CFN2CDC42319Cell division cycle 42
G protein–coupled receptorsQ3KRC4GPRC5C28G protein–coupled receptor class C group 5 member C
Ion channelsQ9Z0W7CLIC41064Chloride intracellular channel 4
Q9Z0Y8CACNA1I27Calcium voltage-gated channel subunit α1 I
Q91YD4TRPM226Transient receptor potential cation channel subfamily M member 2
KinasesQ01279EGFR49EGF receptor
Other proteinsP31977EZRI28241Ezrin
Q9R0T4CADH113204Cadherin 1
Q9JJ19NHRF125131SLC9A3 regulator 1
PeptidasesP15684AMPN30418Alanyl aminopeptidase, membrane
P07861NEP34361Membrane metalloendopeptidase
P14740DPP431289Dipeptidyl peptidase 4
Transmembrane proteinsP07151B2MG8143β-2-Microglobulin
O70244CUBN1758Cubilin
Q63257IL4RA448IL-4 receptor
TransportersP98158LRP2106651LDL receptor-related protein 2/megalin
Q64319SLC3A131427Solute carrier family 3 member 1
Q9JJ40NHRF320152PDZ domain-containing 1
P29975AQP18151Aquaporin 1
P15083PIGR21134Polymeric Ig receptor
Q62687S6A181286Solute carrier family 6 member 18
Q63424S15A21659Solute carrier family 15 member 2
Q9WTW7S23A11143Solute carrier family 23 member 1
Q80W57ABCG2933ATP binding cassette subfamily G member 2
P50516VATA932ATPase H+ transporting V1 subunit A
  • This table summarizes the three most abundant proteins (by scan count and if present) within each functional category (type) of select cellular locations identified by Ingenuity Pathway Analysis. The ten most abundant transport proteins in the plasma membrane are indicated. UniProt accession numbers, protein symbols, and Entrez gene name are also provided. See Supplemental Table 1 for a complete list of Ingenuity Pathway Analysis–identified protein location/types. SLC9A3, sodium-hydrogen antiporter 3; FMN, flavin mononucleotide; H+, hydrogen ion.