Table 2.

Hazard ratios (95% CIs) of incident sepsis as a function of baseline fibroblast growth factor 23 concentrations

MeasureQuartile 1 (<53 RU/ml)Quartile 2 (53–70 RU/ml)Quartile 3 (70.1–101 RU/ml)Quartile 4 (>101 RU/ml)Per Doubling of FGF23
N233255243260991
Events107118181297703
Model 1aReference1.08 (0.76 to 1.53)1.55 (1.10 to 2.16)2.32 (1.65 to 3.27)1.37 (1.22 to 1.54)
Model 2bReference0.96 (0.66 to 1.40)1.25 (0.86 to 1.82)1.62 (1.10 to 2.37)1.21 (1.06 to 1.39)
Model 3cReference0.81 (0.54 to 1.21)0.95 (0.63 to 1.43)0.97 (0.62 to 1.51)1.01 (0.85 to 1.21)
  • a Model 1 is adjusted for age, sex, race, region of recruitment, annual family income, and educational attainment.

  • b Model 2 is adjusted for variables in model 2 plus current smoking, body mass index, diabetes status, physical activity, and chronic pulmonary disease status.

  • c Model 3 is adjusted for variables in model 3 and eGFR, log-transformed urine albumin-creatinine ratio, and log-transformed high-sensitivity C-reactive protein.