Table 1.

Clinical presentation of patients with fibrillary GN from the most recent case series

CharacteristicsNasr et al. (10)Javaugue et al. (11)Payan Schober et al. (13)Nasr et al. (6)Andeen et al. (18)
Sample size (n)66274284266
Age (yr)53±1259 (25–82)54±1059 (21–80)61 (24–87)
Female (%)36 (55%)11 (41%)25 (60%)74 (62%)173 (65%)
White (%)63 (95%)NA30 (71%)NA103 (87%)a
Diabetes (%)13 (20%)6 (22%)28 (70%)20 (24%)60 (22%)
Hypertension (%)47 (71%)19 (70%)NA52 (62%)144 (54%)
Associated conditions, n (%)
 Hepatitis C infection2 (3%)2 (7%)7 (27%)6 (7%)43 (16%)
 Autoimmune diseases10 (15%)8 (30%)4 (10%)12 (14%)25 (9%)
 Hematologic malignancy6 (9%)0 (0%)0 (0%)3 (4%)6 (2%)
 Solid organ malignancy9 (14%)1 (4%)6 (12%)5 (6%)14 (5%)
Serum studies
 Serum creatinine (mg/dl)2.1 (0.5–8.3)NA3.2±42.5 (0.4–12.8)2.1 (1.46–3.45)b
 Hypocomplementemia, n (%)1 (2%)NA2 (9%)NA6 (2%)
Urinary studies
 Urine protein at biopsy (g/d)5.62 (0.2–20.4)3.2 (0.5–17)5.7±55.1 (0–20)NA
 Nephrotic syndrome, n (%)24 (38%)11 (41%)NA21 (25%)39 (15%)
 Hematuria, n (%)33 (52%)19 (73%)36 (97%)76 (90%)104 (39%)
  • Continuous data represented by either mean±SD or median (range or interquartile range) depending on original reports. Categoric data represented by number (n) and percentage (%). Percentages represented in categoric data use the number of available tests or data as the denominator. NA, not available.

  • a A total of 118 patients had ethnicity information.

  • b The values are interquartile range.