Table 2.

Predictors of number of hypoglycemic events: univariate analysis

Univariate VariableComparisonEstimated Coefficient (SEM)Unadjusted Rate Ratio (95% CI)P Value
Age per 1 yr0.01 (0.002)1.01 (1.007 to 1.013)0.0001
SexFemale versus male0.46 (0.03)1.581 (1.481 to 1.688)0.0001
RaceAsian versus white−0.27 (0.05)0.762 (0.687 to 0.846)0.0001
Black versus white0.22 (0.04)1.241 (1.14 to 1.35)0.0001
EthnicityHispanic versus not Hispanic−22.19 (79.0)Extremely small0.99
Body mass index per one unit (kg/m2)−0.04 (0.003)0.963 (0.957 to 0.969)0.0001
Years of kidney diseases (per yr)−0.09 (0.004)0.917 (0.909 to 0.925)0.0001
Fasting blood glucose (per mg/dl)−0.01 (0.0003)0.989 (0.988 to 0.99)0.0001
Serum creatinine (per mg/dl)0.07 (0.008)1.075 (1.058 to 1.092)0.0001
Serum albumin (per g/L)0.006 (0.001)1.006 (1.005 to 1.008)0.0001
eGFR (per ml/min)−0.008 (0.001)0.993 (0.99 to 0.995)0.0001
Hemoglobin (per g/dl)−0.22 (0.006)0.805 (0.796 to 0.815)0.0001
HbA1c (per 1%)−0.38 (0.01)0.687 (0.669 to 0.706)0.0001
Serum fructosamine, µmol/L−0.004 (0.003)0.996 (0.995 to 0.997)0.0001
Average blood glucose (per 1 mg/dl)−0.02 (0.006)0.977 (0.975 to 0.978)0.0001
CADYes versus no0.21 (0.03)1.231 (1.154 to 1.312)0.0001
CHFYes versus no0.44 (0.03)1.552 (1.455 to 1.655)0.0001
HypertensionYes versus no0.88 (0.12)2.409 (1.912 to 3.039)0.0001
Stroke historyYes versus no0.16 (0.04)1.177 (1.096 to 1.264)0.0001
History of malignancyYes versus no0.43 (0.05)1.531 (1.386 to 1.692)0.0001
Medications
 SulfonylureasYes versus no0.15 (0.03)1.157 (1.082 to 1.237)0.0001
 Any insulinYes versus no0.67 (0.04)1.949 (1.821 to 2.087)0.0001
 Insulin with SUYes versus no1.18 (0.04)3.267 (3.048 to 3.508)0.0001
 Oral other than SUYes versus no−0.06 (0.03)0.945 (0.887 to 1.008)0.08
  • Outcome variable: number of >15 min events with glucose <60 mg/dl; n=80. HbA1c, hemoglobin A1c; CAD, coronary artery disease; CHF, congestive heart failure; SU, sulfonylureas.