Table 4.

Multivariable analysis of predictors associated with key outcomes in the use of ACEI or ARB during hospitalization

Predictors (N=80)Probability of ICU Admission(odds ratio; 95% CI)Probability of Death(odds ratio; 95% CI)Peak CRP, mg/dlPeak Inflammation Score
Estimated Effect (SEM)P ValueEstimated Effect (SEM)P Value
Age, yr1.06 (1.00 to 1.12)1.12 (1.03 to 1.21)a0.21 (0.15)0.160.00 (0.05)0.96
Continuation of ACEI or ARB during hospitalization0.25 (0.08 to 0.81)b0.31 (0.08 to 1.26)−6.85 (3.05)0.03−2.29 (1.08)0.04
AKI on admission2.12 (0.43 to 10.40)1.69 (0.26 to 10.96)2.82 (3.98)0.480.59 (1.39)0.67
sCr on admission1.85 (0.93 to 3.65)1.30 (0.52 to 3.25)0.47 (1.89)0.800.25 (0.67)0.71
eGFR on admission1.05 (1.00 to 1.09)b1.02 (0.96 to 1.08)0.08 (0.11)0.440.02 (0.04)0.54
Potassium on admission1.33 (0.49 to 3.60)1.23 (0.39 to 3.86)−2.14 (2.52)0.400.20 (0.89)0.83
MAP on admission1.04 (0.99 to 1.09)1.04 (0.98 to 1.10)0.13 (0.11)0.250.02 (0.04)0.62
  • Variables included in the multivariable analysis are based on select variables from the exploratory analysis.

  • For categoric values, odds ratios with 95% CIs are present. For continuous variables, estimated effects with SEMs are presented with associated P values. ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ICU, intensive care unit; CRP, C-reactive protein; sCr, serum creatinine; MAP, mean arterial pressure.

  • a P<0.05.

  • b P<0.01.