Table 2.

KidneyIntelX thresholds for the composite kidney end point with sensitivity, specificity, PPV and NPV for T2D and APOL1-HR populations in high- and low-risk strata

ThresholdRisk CutoffSensitivitySpecificityPPVNPV
T2D KidneyIntelX
 Bottom 50%0.1920.820.590.380.92
 Top 20%0.4440.500.890.580.86
 Top 15%0.5550.400.930.620.84
 Top 10%0.7070.290.960.680.82
T2D clinical model
 Bottom 50%0.1480.680.550.310.85
 Top 20%0.2400.380.850.430.82
 Top 15%0.2780.300.890.460.81
 Top 10%0.3380.230.940.540.80
APOL1-HR KidneyIntelX
 Bottom 50%0.2090.880.580.320.96
 Top 20%0.4380.600.890.560.91
 Top 15%0.4890.520.930.620.90
 Top 10%0.5460.360.960.660.87
APOL1-HR clinical model
 Bottom 50%0.1510.790.570.290.93
 Top 20%0.3220.420.850.380.87
 Top 15%0.3870.320.870.390.85
 Top 10%0.4480.220.930.400.84
  • Risk Cutoff, predicted probability of the composite kidney end point; PPV, positive predictive value; NPV, negative predictive value; T2D, type 2 diabetes; APOL1-HR, high-risk APOL1.