Table 4.

Neurologic side effects of immunosuppressants used in kidney transplantation

DrugSide Effect
Calcineurin inhibitorsMild: tremor, headache, insomnia, vivid dream imagery, photophobia
Moderate: visual and cortical disturbances
Severe: encephalopathy, convulsion, coma, and flaccid quadriparesis
SteroidsInsomnia, anxiety, psychosis, myopathy, mania, depression
BortezomibDistal peripheral neuropathy
Mammalian target of rapamycin inhibitorSympathetic dystrophy, rarely PRES and possible potentiation of calcineurin-inhibitor toxicity
BelataceptCentral neurologic system post-transplant lymphoproliferative disorder
AlemtuzumabSensorimotor polyneuropathy and myelitis
RituximabProgressive multifocal leukoencephalopathy
  • PRES, posterior reversible encephalopathy syndrome.