Table 3.

Neurologic side effects of calcineurin inhibitors

SeverityCentral ToxicityPeripheral Toxicity
MinorInsomnia, visual disturbances, headache, and mood changesParaesthesias, peripheral neuropathy, and myopathy
MajorPRES, akinetic mutism, toxic encephalopathy, and convulsionsAxonal and demyelinating neuropathy, Guillain–Barré syndrome
  • PRES, posterior reversible encephalopathy syndrome.