Table 1.

Biopsy characteristics including date, indication, brief clinical history, and final diagnosis

CaseBiopsy TypeBiopsy DateBiopsy IndicationClinical HistoryBiopsy Diagnosis
1NApril 2020Proteinuria (10 g), increased Cr (1.7)33 yr F with DM2, CHFDiffuse and nodular glomerulosclerosis, consistent with diabetic nephropathy, class 3
2NApril 2020AKI (Cr 2.7), low C475 yr M with HTN, hyperlipidemia, CVA, lung cavitary lesionsMesangiopathic immune complex disease, most consistent with resolving-phase infectious glomerulonephritis
3NApril 2020AKI (Cr 8.4)46 yr M with hematuria, hemoptysis, and weaknessDiffuse crescentic and necrotizing GN, pauci-immune (ANCA-associated) type
4NApril 2020AKI (Cr 1.5)33 yr M with h/o methamphetamine abuseThrombotic microangiopathy
5NMarch 2020Rapid decline of renal function72 yr M with DM2, HTN on hydralazine. Positive ANA (1:640) and ANCAMesangiopathic immune complex disease, suspicious for autoimmune diseases such as lupus or lupus-like conditions
6NMarch 2020History of IgAN, now nephrotic-range proteinuria40 yr, Cr 1.3;UA: 3+ blood, 3+ proteinIgAN with focal cellular crescents and fibrinoid necrosis
7TMarch 2020AKI (Cr 7.9)47 yr M with ESKD from DM/HTNAcute cellular rejection, Banff IB
Acute vascular rejection, Banff IIB
C4d negative
SV-40 negative
8TMarch 2020AKI (Cr 2.7)55 yr M with ESKD from RCC requiring bilateral nephrectomiesBorderline changes by Banff criteria (suspicious for acute cellular rejection)
C4d negative
SV-40 negative
9TMarch 2020AKI (Cr 4.3), anemia, leukopenia28 yr M with ESKD of unknown etiologyAcute cellular rejection, Banff IB
Acute vascular rejection, Banff IIB
C4d negative
SV-40 negative
10TFebruary 2020AKI (Cr 5.1)36 yr F with h/o ESKD due to SLE. Admitted with pulmonary HTN, acute decompensated HFpEF, and AKI. DSAs negativeNegative for rejection
Findings favor thrombotic microangiopathy
C4d negative
SV-40 negative
11TOctober 2019AKI (Cr 6.5)49 yr M with ESKD from DM/HTN s/p DDKT with DGFNegative for rejection
C4d negative
SV-40 negative
12TOctober 2019AKI (Cr 1.7)53 yr with ESKD from DM2Borderline changes by Banff criteria
C4d negative
SV-40 negative
13TOctober 2019AKI (Cr 4.6)38 yr M with HTN, AFib, HLPD, s/p kidney transplant with diarrheaAcute cellular rejection, Banff IA
C4d positive
SV-40 negative
14TOctober 2019Pain over allograft, AKI (Cr 1.8)40 yr M with ESKD from HTN/DMBK polyomavirus nephropathy
Negative for rejection
C4d negative
SV-40 positive
15TOctober 2019AKI (Cr 2.7)67 yr F with ESKD from DM/HTNBorderline changes by Banff criteria
C4d negative
SV-40 negative
  • N, native kidney; Cr, creatinine (all values are in mg/dl; reference range, 0.6–1.3 mg/dl); F, female; DM2, type 2 diabetes mellitus; CHF, congestive heart failure; M, male; HTN, hypertension; CVA, cerebrovascular accident; h/o, history of; ANA, anti-nuclear antibodies; IgAN, IgA nephropathy; UA, urinalysis; T, transplant kidney; SV-40, simian virus 40; RCC, renal cell carcinoma; HFpEF, heart failure with preserved ejection fraction; DSA, donor-specific antibody; s/p, status post; DDKT, deceased donor kidney transplant; DGF, delayed graft function; AFib, atrial fibrillation; HLPD, hyperlipidemia.