Table 3.

Summary of individual patient outcomes

Patient No.Donor TypeMaintenance ImmunosuppressionCause of ESKDcPRA (%)RegraftRejection Pre-TCZTVZ Doses (no.)Immunologic OutcomesClinical OutcomesHistologic OutcomesMolecular Diagnostic ScoresGraft and Patient Survival OutcomesAdverse Events
Pre-DSA Class IPre-DSA Class IIPost-DSA Class IPre-total DSA (MFI)Post-Total DSA (MFI)Pre-Scr (mg/dl)Pre-eGFR (ml/min per 1.73m2)Post-Scr (mg/dl)Post-GFR (ml/min per 1.73m2)UPCR At TCZ (g/g)UPCR Recent (g/g)Pre ci+ct+cv+cgPost ci+ct+cv+cg-Pre g+ptc-Post g+ptcPre-rejection ScorePost-rejection ScorePre-AbMR ScorePost-AbMR ScoreDeathGraft Loss
1LKTT+M+BelaIgAN0NoYes7NoYesNo13,67923,2942.85253.32201.81.57NA4NA0.83NA0.97NANoNoNone
2LKTT+M+BelaHTN24NoYes9NoYesNo15,47055502.37304.45140.51.324660.980.960.980.99NoYesUTI, bacteremia, diarrhea, leukopenia
3LKTT+M+BelaADPKD2NoYes6NoNoNo002.5301.94412.92.3711560.950.920.950.99NoNoLeukopenia, vaginal HSV infection
4DDKTT+M+BelaDM/HTN100YesYes3YesNo2870NA2.0242NANA2.30.54NA2NA0.73NA0.87NAYesNoNone
5LKTT+M+BelaHTN2NoYes5NoYesNo164002.71323.02281.44.95NA3NA0.83NA0.79NANoNoBacteremia, hip infection, diarrhea
6DDKTT+M+PFSGS97YesYes10NoYesNo876031831.36761.23850.10.151330.650.690.60.79NoNoClostridium difficile–associated diarrhea
7DDKTT+M+BelaFSGS88YesYes10NoYesNo14,68715,1091.33571.31580.10.135320.860.610.670.35NoNoNone
8LKTT+M+BelaPCKD62YesYes6NoYes1975NA3.5616NANA3.575NA3NA0.4NA0.25NANoYesNone
9DDKTT+M+PMembranous nephropathy0NoNo6NoYesNo394324711.8945NANA1.50.33562NA0.92NA0.88NoNoNone
10LKTT+M+PPCKD40NoNo6NoNoNo05801.0463NANA20.568660.710.770.760.76NoNoNone
  • cPRA, calculated panel-reactive antibodies; TCZ, tocilizumab; DSA, donor-specific antibody; MFI, mean fluorescence intensity; Scr, serum creatinine; ci, interstitial fibrosis score; ct, tubular atrophy score; cv, vascular intimal thickening score; cg, chronic glomerular damage score; g, glomerulitis score; ptc, peritubular capillaritis score; AbMR, antibody-mediated rejection; LKT, living donor kidney transplant; T, tacrolimus; M, mycophenolate; Bela, belatacept; IgAN, IgA nephropathy; NA, not available; HTN, hypertension; UTI, urinary tract infection; ADPKD, autosomal dominant polycystic kidney disease; HSV, herpes simplex virus; DDKT, deceased donor kidney transplant; DM, diabetes; P, prednisone; PCKD, polycystic kidney disease.