Table 2.

Vascular parameters in participants with CKD and controls

VariableCKD (n=64)Control (n=17)P Value
FMDBA (%)3.5±2.85.5±3.20.02
FMDBA (mm)0.14±0.100.20±0.110.04
Baseline FMD diameter (mm)4.1±0.73.7±0.60.02
Resting shear rate (s−1)132±47121±380.39
Hyperemic shear rate (s−1)644±225831±2710.01
Time to peak FMDBA (s)57±2244±160.03
Brachial artery dilation to nitroglycerin (%)18.2±9.726.0±7.30.01
Baseline nitroglycerin diameter (mm)4.1±0.73.8±0.60.13
Carotid-femoral PWV (cm/s)1071±336732±128<0.001
Carotid-radial PWV (cm/s)1003±246955±1650.46
Carotid artery compliance (mm/mm Hg×10−1)0.76±0.320.78±0.180.65
Carotid β-stiffness index (A.U.)11.8±4.68.7±2.0<0.001
Carotid IMT (mm)0.67±0.190.58±0.090.04
Carotid systolic BP (mm Hg)134±19116±170.001
Brachial mean arterial BP (mm Hg)90±1487±100.41
  • Data are mean±SD. n=14 controls and n=49 participants with CKD were administered nitroglycerin. n=56 participants with CKD and all (n=17) control participants had measurements of carotid artery compliance and β-stiffness index. n=64 participants with CKD and all (n=17) control participants had measurements of carotid IMT. N=62/N=63 participants with CKD and n=16/n=17 control participants had successful measurements of carotid-femoral PWV and carotid-radial PWV, respectively. All vascular parameters were assessed in the supine position. FMDBA, brachial artery flow-mediated dilation; PWV, pulse-wave velocity; IMT, intimal medial thickness.