Table 3.

Correlations of baseline inflammatory biomarkers with clinical variables

VariableAlbumin Spearman rhoPrealbumin Spearman rhohsCRP Spearman rhoIL-6 Spearman rho
Age, yr0.029−0.345a0.0340.179b
eGFR, ml/min per 1.73 m20.207a0.068−0.020−0.187b
CCI−0.162b−0.313a0.0950.241a
Albumin-to-creatinine ratio, mg/g−0.538a0.0030.0790.176b
QIDS-C16
 Total score0.0510.0410.162b0.017
 Somatic subscale total−0.025−0.0530.205b0.036
 Sleep−0.0330.0120.027−0.011
 Appetite/weight−0.116−0.184b0.0800.051
 Concentration0.151b0.0470.035−0.093
 Fatigue−0.0650.0200.223a0.128
 Psychomotor agitation/retardation0.0250.0050.1240.007
 Nonsomatic subscale total0.0910.0580.1030.031
 Sadness0.0850.0920.1090.011
 Self-perception0.0180.0120.032−0.008
 Suicide0.104−0.0830.0470.002
 Anhedonia0.0510.1300.1310.071
KDQOL-SF 1.3 subscales
 Kidney disease component
  Burden of kidney disease0.059−0.123−0.041−0.015
  Symptoms/problems0.103−0.012−0.008−0.050
  Effects of kidney disease0.053−0.085−0.075−0.086
  Work status0.0300.079−0.160b−0.289a
  Cognitive function−0.130−0.167b0.1080.146b
  Quality of social interaction−0.102−0.225a0.0330.028
  Sexual function0.085−0.018−0.152−0.319b
  Sleep0.012−0.143−0.123−0.021
  Social support−0.0300.017−0.056−0.052
  Patient satisfaction−0.024−0.067−0.038−0.022
 Physical functioning component
  Physical functioning0.212a0.111−0.263a−0.213a
  Role limits, physical0.032−0.0400.000−0.024
  Pain0.095−0.078−0.125−0.148b
  General health0.111−0.067−0.157b−0.018
 Mental functioning component
  Emotional wellbeing−0.075−0.0900.003−0.026
  Role limits, emotional−0.003−0.0450.009−0.000
  Social function−0.094−0.202a−0.042−0.014
  Energy/fatigue−0.029−0.017−0.121−0.109
  Overall health0.1190.013−0.250a−0.168b
  SF-36 physical composite0.209a0.006−0.198b−0.160b
  SF-36 mental composite−0.100−0.107−0.002−0.002
  SF-12 physical composite0.145−0.030−0.182b−0.130
  SF-12 mental composite−0.073−0.087−0.043−0.061
  • hsCRP, high-sensitivity C-reactive protein; CCI, Charlson Comorbidity Index; QIDS-C16, clinician-rated 16-item Quick Inventory of Depressive Symptomatology scale; KDQOL-SF 1.3, Kidney Disease Quality of Life Survey Short Form, Version 1.3; SF-36, Short Form 36 Health Survey; SF-12, Short Form 12.

  • a P<0.01.

  • b P<0.05.