Table 4.

Normalized counts of all genes studied via targeted RNA sequencing in 6-month-old female rats

GeneVehicle FemaleSildenafil FemaleP Value
Agtr1a0.0230.0180.22
Cat0.7740.7060.47
Col3a10.0510.0530.93
Edn10.0030.0040.84
Ednra0.0010.0010.36
Ednrb0.0640.0760.19
Gpx20.0120.0110.60
Gss0.6050.5060.27
Hmox10.0050.0040.43
Hmox2UndUnd
Hif3a0.0010.0010.62
Il10UndUnd
Il17aUndUnd
Il6UndUnd
Havcr10.0240.0250.89
Nox40.1320.0990.31
Nphs10.0230.0420.002a
Lcn20.0160.0120.44
Nos2UndUnd
Nos30.0050.0070.01a
Pde5a0.0120.0110.69
Nphs20.0790.1180.21
Prkg2UndUnd
Atp6ap20.1780.1690.76
S100a40.0460.0430.91
Sod12.3481.6820.03a
Sod20.6910.5910.22
Sod31.2901.0260.06
Tgfb10.0180.0200.54
Timp10.0310.0310.97
TnfUndUnd
Vim0.1240.1390.48
  • Und, undetectable; —, not applicable.

  • a P<0.05 versus vehicle.