Table 2.

Incidence rates (per 100 person-years [N of event per follow-up year]) for intensive and standard treatment groups, hazard ratios, and 95% confidence intervals for the effect of the intensive versus standard systolic BP intervention on serious adverse events in the Systolic Blood Pressure Intervention Trial participants with CKD by tertile of baseline diastolic BP

Adverse Event TypeLowest tertile <69 mm HgMiddle tertile =69–79 mm HgHighest tertile ≥80 mm Hg
Any serious adverse eventa
 Incidence rate
  Intensive24.3 (223/919)21.6 (218/1010)15.0 (187/1246)
  Standard26.4 (233/883)18.5 (206/1111)18.1 (202/1118)
 HR (95% CI) intensive versus standard0.93 (0.78 to 1.12)1.11 (0.92 to 1.35)0.84 (0.69 to 1.03)
Hypotension
 Incidence rate
  Intensive1.0 (13/1263)1.3 (18/1338)1.1 (17/1525)
  Standard0.9 (11/1238)0.8 (12/1423)0.8 (11/1424)
 HR (95% CI) intensive versus standard1.14 (0.51 to 2.55)1.55 (0.75 to 3.23)1.37 (0.64 to 3.00)
Syncope
 Incidence rate
  Intensive1.3 (16/1264)1.1 (15/1349)0.7 (10/1538)
  Standard0.9 (11/1244)0.8 (12/1426)0.5 (7/1431)
 HR (95% CI) intensive versus standard1.38 (0.64 to 3.00)1.28 (0.60 to 2.74)1.25 (0.46 to 3.37)
Electrolyte abnormality
 Incidence rate
  Intensive1.8 (22/1245)2.0 (27/1324)0.9 (14/1532)
  Standard1.4 (17/1228)0.8 (12/1425)1.1 (16/1408)
 HR (95% CI) intensive versus standard1.37 (0.73 to 2.60)2.33 (1.18 to 4.61)0.73 (0.36 to 1.51)
AKI or acute kidney failure
 Incidence rate
  Intensive3.7 (45/1220)3.1 (41/1302)1.8 (27/1515)
  Standard2.4 (29/1227)1.6 (23/1418)1.9 (27/1394)
 HR (95% CI) intensive versus standard1.53 (0.95 to 2.44)1.81 (1.08 to 3.01)1.00 (0.58 to 1.72)
  • HR, hazard ratio; 95% CI, 95% confidence interval.

  • a Models adjusted for age, sex, race, cardiovascular disease, Framingham 10-year cardiovascular disease risk score ≥15%, smoking history, and baseline eGFR. Likelihood ratio tests comparing HRs for the systolic BP intervention among baseline diastolic BP tertiles were nonsignificant.