Parameter | Value | ||||

D_{5}W infusion, ml/h | 30 | 80 | 160 | 240 | 300 |

CHO load, mg/kg·min | 0.28 | 0.74 | 1.48 | 2.22 | 2.78 |

P_{Glu}, without carbohydrate metabolism for 24-h, mg/dl | 125 | 500 | 1100 | 1700 | 2150 |

Maintenance metabolic rate, mg/kg·min | 0.15 | 0.62 | 1.36 | 2.10 | 2.65 |

Prehemofilter P_{Na}, mM | 117.0 | 117.0 | 116.9 | 116.8 | 116.8 |

The effects of a 5% dextrose infusion on glucose metabolism in a hypothetical, nondiabetic, 42-year-old, 178-cm, 90-kg man with Watson volume 48 L and P

_{Na}(0) 116 mM (see text,*Case 1*) after 24 hours of CVVH are displayed. CVVH parameters are: Na_{RF}, 130 mM; Q_{P}, 225 ml/min; combined prehemofilter RF and posthemofilter D_{5}W flow rate, 1.1 L/h (18.3 ml/min); and net ultrafiltration rate, 0 ml/min. Calculations are based on an extracellular fluid volume of 16 L (48 L × 0.33), without expansion of the extracellular fluid space from glucose accumulation. All CHO metabolism is assumed to originate from the D_{5}W infusion. With no CHO metabolism, increasing the CHO load (row 2) by increasing the D_{5}W infusion rate from 0 to 300 ml/h rapidly increases P_{Glu}(row 3). The respective glucose metabolic rates required to maintain P_{Glu}at 100 mg/dl for increasing D_{5}W infusion rates are shown (row 4). The minimal dilutional effect of the increasing D_{5}W infusion rate on hemofilter inlet P_{Na}is shown (row 5). CVVH, continuous venovenous hemofiltration; D_{5}W, 5% dextrose solution; CHO, carbohydrate; P_{Glu}, plasma glucose concentration; P_{Na}(0), plasma [Na] at time (t) = 0; Na_{RF}, RF [Na]; Q_{P}, plasma flow rate; RF, unadjusted replacement fluid; [Na], sodium concentration.