Table 3.

Time-dependencies of plasma sodium concentration and sodium concentration adjustment ratio during sodium-based osmotherapy

Time (t, min)PNa(0)NaARΔNa(t) (mM)PNa(t) (mM)
0116.00.0 (0.0)0.0 (0.0)116.0 (116.0)
360116.00.12 (0.14)2.4 (2.9)118.4 (118.9)
720116.00.23 (0.27)4.5 (5.4)120.5 (121.4)
1080116.00.32 (0.37)6.4 (7.5)122.4 (123.5)
1440116.00.40 (0.47)8.0 (9.3)124.0 (125.3)
2880116.00.64 (0.71)12.8 (14.3)128.8 (130.3)
4320116.00.78 (0.85)15.7 (16.9)131.7 (132.9)
  • Predilution continuous venovenous hemofiltration is carried out on a hypothetical 42-year-old, 178-cm, 90-kg man with PNa(0) 116 mM and Watson volume 48.0 L for times shown. The replacement fluid is adjusted from a nominal [Na] of 140 mM to 136 mM to achieve a 20 mM [Na] gradient. Values in parentheses are those of a 42-year-old woman with a Watson volume of 39.1 L, treated with the same parameters. PNa, plasma sodium concentration; NaAR, sodium concentration adjustment ratio; ΔNa(t), PNa(t) minus PNa(0); PNa(t), PNa at time (t); [Na], sodium concentration; PNa(0), PNa at time (t) = 0.