Table 1.

Clinical characteristics of sampled diabetic and nondiabetic patients with FSGS and membranous nephropathy at the Center for Glomerular Diseases of Columbia University

CharacteristicsDiabetic CohortAge-Matched CureGN ControlsP Value
FSGS, n2244
 Age at first biopsy, yr60.0±11.759.5±11.80.90
 Serum creatinine, mmol/L2.54±2.851.94±0.970.20
 eGFR, ml/min per 1.73 m247.0±36.2a41.5±19.9a0.40
 Proteinuria, g/g or g/d7.1±4.65.0±4.40.09
MN, n2652
 Age at first biopsy, yr61.3±11.161.3±11.1>0.99
 Serum creatinine, mmol/L1.35±0.681.39±0.780.80
 eGFR, ml/min per 1.73 m262.0±29.463.2±31.50.90
 Proteinuria, g/g or g/d10.3±7.87.2±5.80.03
 Hematuria (dipstick), n (%)0.005
  None/trace11 (43.2)30 (57.7)
  1+3 (11.5)10 (19.2)
  2+6 (23.1)4 (7.7)
  3+6 (23.1)3 (5.8)
  Unknown05 (9.6)
 Anti-PLA2R variant, n (%)0.01
  Positive10 (38.5)28 (53.8)
  Negative13 (50.0)11 (21.2)
  Unknown3 (11.5)13 (25.0)
  • CureGN, Cure Glomerulopathy Network; MN, membranous nephropathy; PLA2R, phospholipase A2 receptor.

  • a Differences in eGFR attributed to 23% black representation in the diabetic cohort versus 14% black representation in the control group.