Pretransplant dialysis and preemptive transplant in living donor kidney recipients

Abstract

Background: The optimal timing of dialysis access placement in individuals with stage 5 chronic kidney disease is challenging to estimate. Preemptive living donor kidney transplant (LDKT) is the gold standard treatment for end stage renal disease due to superior graft survival and mortality, but dialysis initiation is often required. Among LDKT recipients, we sought to determine which clinical characteristics were associated with preemptive transplant. Among non-preemptive LDKT recipients, we sought to determine what dialysis access was used, and their duration of use prior to receipt of living donor transplant. Methods: We retrospectively extracted data on 569 LDKT recipients over 18 years old transplanted between January 2014 and July 2019 at UCSF, including dialysis access type (arteriovenous fistula [AVF], arteriovenous graft [AVG], peritoneal dialysis catheter [PD], and venous catheter), duration of dialysis, and clinical characteristics. Results: Preemptive LDKT recipients constituted 29.7% of our cohort and were older, more likely to be white, more likely to have ESRD from polycystic kidney disease and less likely from type II diabetes. 25.8% of non-preemptive patients used AVF, 0.5% used AVG, 31.8% used peritoneal catheter, 10.8% used venous catheter, 31.3% used more than one access type. Median (IQR) time on dialysis for AVF/AVG use was 1.86 (0.85-3.32) years, PD catheters 1.12 (0.55-1.92) years, venous catheters 0.66 (0.23-1.69) years and multimodal access 2.15 years (1.37-3.72). Conclusions: We characterize the dialysis access landscape in living donor kidney transplant recipients. Venous catheter and PD were the most popular modality in the first quartile of dialysis and had shorter times on dialysis compared to AVF use. Venous catheter or PD can be considered a viable bridge therapy in patients with living donor availability given their shorter waitlist times. Earlier referral of patients with living donor prospects might further minimize dialysis need.