Skip to main content

Main menu

  • Home
  • Content
    • Early Access
    • Current Issue
    • Kidney360 Podcasts
    • Subject Collections
    • Archives
    • Kidney Week Abstracts
    • Saved Searches
  • Clinical Images
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
    • Editorial Team
    • Editorial Training Program
    • Reviewer Recognition
  • More
    • About Kidney360
    • Advertising
    • Email Alerts
    • Feedback
    • Reprint Information
  • ASN Kidney News
  • Other
    • ASN Publications
    • JASN
    • CJASN
    • Kidney News Online
    • American Society of Nephrology

User menu

Search

  • Advanced search
American Society of Nephrology
  • Other
    • ASN Publications
    • JASN
    • CJASN
    • Kidney News Online
    • American Society of Nephrology
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Early Access
    • Current Issue
    • Kidney360 Podcasts
    • Subject Collections
    • Archives
    • Kidney Week Abstracts
    • Saved Searches
  • Clinical Images
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
    • Editorial Team
    • Editorial Training Program
    • Reviewer Recognition
  • More
    • About Kidney360
    • Advertising
    • Email Alerts
    • Feedback
    • Reprint Information
  • ASN Kidney News
  • Visit ASN on Facebook
  • Follow Kidney360 on Twitter
  • Community Forum
  • Kidney360 RSS
Original InvestigationGenetics

Association of Blood Pressure Genetic Risk Score with Cardiovascular Disease and CKD Progression: Findings from the CRIC Study

Jovia L. Nierenberg, Amanda H. Anderson, Jiang He, Afshin Parsa, Anand Srivastava, Jordana B. Cohen, Santosh L. Saraf, Mahboob Rahman, Sylvia E. Rosas, Tanika N. Kelly and CRIC Study Investigators
Kidney360 August 2021, 2 (8) 1251-1260; DOI: https://doi.org/10.34067/KID.0007632020
Jovia L. Nierenberg
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jovia L. Nierenberg
Amanda H. Anderson
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiang He
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
2Department of Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jiang He
Afshin Parsa
3Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, Maryland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anand Srivastava
4Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anand Srivastava
Jordana B. Cohen
5Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jordana B. Cohen
Santosh L. Saraf
6Division of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Santosh L. Saraf
Mahboob Rahman
7Division of Nephrology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sylvia E. Rosas
8Kidney and Hypertension Unit, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanika N. Kelly
1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tanika N. Kelly
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

Visual Abstract

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

Abstract

Background In the general population, genetic risk for high BP has been associated with cardiovascular disease, but not kidney function or incident CKD. These relationships have not been studied longitudinally in participants with CKD. We examined whether BP genetic risk predicts cardiovascular disease and kidney disease progression in patients with CKD.

Methods We included 1493 African- and 1581 European-ancestry participants from the Chronic Renal Insufficiency Cohort who were followed for 12 years. We examined associations of BP genetic risk scores with development of cardiovascular disease (myocardial infarction, congestive heart failure, or stroke) and CKD progression (incident ESKD or halving of eGFR) using Cox proportional hazards models. Analyses were stratified by race and included adjustment for age, sex, study site, and ancestry principal components.

Results Among European-ancestry participants, each SD increase in systolic BP and pulse pressure genetic risk score conferred a 15% (95% CI, 4% to 27%) and 11% (95% CI, 1% to 23%), respectively, higher risk of cardiovascular disease, with a similar, marginally significant trend for diastolic BP. Among African-ancestry participants, each SD increase in systolic and diastolic BP genetic risk score conferred a 10% (95% CI, 1% to 20%) and 9% (95% CI, 0% to 18%), respectively, higher risk of cardiovascular disease. Higher genetic risk was not associated with CKD progression.

Conclusions Genetic risk for elevation in BP was associated with increased risk of cardiovascular disease, but not CKD progression.

  • genetics
  • blood pressure
  • cardiovascular disease
  • chronic kidney disease
  • CRIC Study
  • disease progression
  • genetic risk score
  • Received December 23, 2020.
  • Accepted March 30, 2021.
  • Copyright © 2021 by the American Society of Nephrology

View Full Text
PreviousNext
Back to top

In this issue

Kidney360: 2 (8)
Kidney360
Vol. 2, Issue 8
26 Aug 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • About the Cover
  • Index by author
View Selected Citations (0)
Print
Download PDF
Sign up for Alerts
Email Article

Thank you for your interest in spreading the word on American Society of Nephrology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Association of Blood Pressure Genetic Risk Score with Cardiovascular Disease and CKD Progression: Findings from the CRIC Study
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Association of Blood Pressure Genetic Risk Score with Cardiovascular Disease and CKD Progression: Findings from the CRIC Study
Jovia L. Nierenberg, Amanda H. Anderson, Jiang He, Afshin Parsa, Anand Srivastava, Jordana B. Cohen, Santosh L. Saraf, Mahboob Rahman, Sylvia E. Rosas, Tanika N. Kelly, CRIC Study Investigators
Kidney360 Aug 2021, 2 (8) 1251-1260; DOI: 10.34067/KID.0007632020

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Association of Blood Pressure Genetic Risk Score with Cardiovascular Disease and CKD Progression: Findings from the CRIC Study
Jovia L. Nierenberg, Amanda H. Anderson, Jiang He, Afshin Parsa, Anand Srivastava, Jordana B. Cohen, Santosh L. Saraf, Mahboob Rahman, Sylvia E. Rosas, Tanika N. Kelly, CRIC Study Investigators
Kidney360 Aug 2021, 2 (8) 1251-1260; DOI: 10.34067/KID.0007632020
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Visual Abstract
    • Abstract
    • Introduction
    • Methods
    • Results
    • Discussion
    • Disclosures
    • Funding
    • Acknowledgments
    • Author Contributions
    • Supplemental Materials
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

Original Investigation

  • Safety and efficacy of patiromer in CKD
  • New equations predicting mortality in CRRT patients
  • PTSD and PTG after Kidney Transplantation
Show more Original Investigation

Genetics

  • Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/β-Catenin Signaling
  • The KIDNEYCODE Program: Diagnostic Yield and Clinical Features of Individuals with CKD
  • Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model
Show more Genetics

Cited By...

  • No citing articles found.
  • Google Scholar

Similar Articles

Related Articles

  • Genetic Risk Scores and Blood Pressure — The Heart is What Matters
  • Google Scholar

Keywords

  • genetics
  • blood pressure
  • cardiovascular disease
  • chronic kidney disease
  • CRIC Study
  • disease progression
  • genetic risk score

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Author Resources
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • Kidney360
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About Kidney360
  • Kidney360 Email Alerts
  • Kidney360 Podcasts
  • Kidney360 RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Subscribe to JASN and CJASN
  • Wolters Kluwer Partnership

© 2022 American Society of Nephrology

Online ISSN - 2641-7650

Powered by HighWire