Skip to main content

Main menu

  • Home
  • Content
    • Early Access
    • Current Issue
    • Kidney360 Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
  • Clinical Images
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • More
    • About Kidney360
    • Advertising
    • Disqus Commenting
    • Reprint Information
    • Feedback
    • Email Alerts
  • ASN Kidney News
  • Other
    • JASN
    • CJASN
    • Kidney News Online
    • American Society of Nephrology

User menu

Search

  • Advanced search
American Society of Nephrology
  • Other
    • JASN
    • CJASN
    • Kidney News Online
    • American Society of Nephrology
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Early Access
    • Current Issue
    • Kidney360 Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
  • Clinical Images
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Editorial Team
  • More
    • About Kidney360
    • Advertising
    • Disqus Commenting
    • Reprint Information
    • Feedback
    • Email Alerts
  • ASN Kidney News
  • Visit ASN on Facebook
  • Follow Kidney360 on Twitter
  • Community Forum
  • Kidney360 RSS

About the Cover

January 28, 2021; Volume 2,Issue 1

Cover image

On the Cover

Proposed functions of resident macrophages during cyst formation and expansion. Multiple processes occur during cyst formation and expansion including increased epithelial proliferation and apoptosis, interstitial inflammation, increased extracellular matrix deposition and renal fibrosis, as well as vasculature abnormalities. Resident macrophages may be involved in controlling several of these processes directly or indirectly. It has been proposed that resident macrophages can promote cystic epithelial proliferation by secretion of cytokines and phagocytosis of apoptotic epithelial cells. Also, renal resident macrophages may drive interstitial myofibroblast activation and proliferation, leading to increased extracellular matrix deposition and renal fibrosis. Resident macrophages may serve as “first responders” in the kidney and control the accumulation and effector function of other immune cells, like neutrophils, infiltrating macrophages, and T cells, to indirectly regulate cyst formation. Finally, renal resident macrophages may also regulate vasculature abnormalities through their proposed pro-angiogenic functions. The inset indicates the reciprocal communication between resident macrophages and the cilia mutant epithelium via mb-CSF1/CSF-1R. ECM: extracellular matrix, mb-CSF1: membrane-bound Colony-Stimulating Factor-1, RM: resident macrophages, IM: infiltrating macrophages. From figure 2 of “Resident macrophages in cystic kidney disease” by Zhang Li, Kurt A. Zimmerman, and Bradley K. Yoder. KIDNEY360 1: 167–175, 2021. doi: 10.34067/KID.0006052020.

Back to top
PreviousNext

In this issue

Kidney360: 2 (1)
Kidney360
Vol. 2, Issue 1
28 Jan 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • About the Cover
  • Index by author
Sign up for alerts
View Selected Citations (0)

Jump to

  • Editorials
  • Patient Perspective
  • Debates in Nephrology
  • Moderator Commentary
  • Original Investigations
    • Acid/Base and Electrolyte Disorders
    • Acute Kidney Injury and ICU Nephrology
    • Chronic Kidney Disease
    • Clinical Nephrology
    • Dialysis
    • Genetics
    • Glomerular and Tubulointerstitial Diseases
  • Innovative Technology and Methodology
    • Geriatric and Palliative Nephrology
  • Global Perspective
  • Basic Science for Clinicians
  • Review Articles
  • Clinical Images in Nephrology and Dialysis
  • Most Read
Loading
  • Acute Abdominal Pain in a COVID-19 Patient
  • Management of Hemodialysis Patients with Suspected or Confirmed COVID-19 Infection: Perspective of Two Nephrologists in the United States
  • Immune Checkpoint Inhibitor Nephrotoxicity: Update 2020
  • Housing Insecurity and Risk of Adverse Kidney Outcomes
  • Gadolinium-Based Contrast Agent Use, Their Safety, and Practice Evolution
More...

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Author Resources
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • Kidney360
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About Kidney360
  • Kidney360 Email Alerts
  • Kidney360 Podcasts
  • Kidney360 RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Disqus Code of Conduct
  • Disqus Information
  • Feedback
  • Follow on Twitter
  • Subscribe to JASN and CJASN

© 2021 American Society of Nephrology

Online ISSN - 2641-7650

Powered by HighWire