Article Figures & Data
Tables
Reference CPI Other ATIN Drugs Kidney Biopsy Shirali et al. (10) (n=6) 3 Nivo 5 PPI 6 ATIN 2 Pembro 1 NSAID 1 Ipi+nivo Cortazar et al. (1) (n=13) 6 Ipi 6 PPI 12 ATIN 1 Nivo 1 NSAID 1 TMA 2 Pembro 3 Antibiotics 4 Ipi+nivo Izzedine et al. (18) (n=12) 12 Pembro 0 5 ATI 4 ATIN 1 MCD+ATI 1 MCD 1 NF Mamlouk et al. (17) (n=16) 6 Nivo 9 PPI 5 ATIN 6 Pembro 3 NSAID 9 ATIN+GN 2 Ipi+nivo 3 Antibiotics 1 ATI 1 Atez 1 NF 1 Trem CPI, checkpoint inhibitor; nivo, nivolumab; PPI, proton pump inhibitor; ATIN, acute tubulointerstitial nephritis; pembro, pembrolizumab; NSAID, nonsteroidal anti-inflammatory drug; ipi, ipilimumab; TMA, thrombotic microangiopathy; ATI, acute tubular injury; MCD, minimal change disease; NF, nonspecific findings; atez, atezolizumab; trem, tremelimumab.
Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor–Associated Acute Kidney Injury: PRO
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- Article
- Introduction
- Cases
- ATIN Is the Most Common IRAE but Also Other Kidney Adverse Events Occur in Patients on CPI Therapy
- Not Performing a Biopsy Will Result in an Erroneous Diagnosis in a Significant Subset of Patients
- Current Guidelines Do Not Value Kidney Biopsy Sufficiently
- Histologic Diagnosis Is Necessary to Guide Treatment (or not)
- CPI Retreatment in Patients with Previous Kidney IRAEs
- Discussion of Cases
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