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Debates in Nephrology

Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor–Associated Acute Kidney Injury: PRO

Mark Eijgelsheim and Ben Sprangers
Kidney360 March 2020, 1 (3) 158-161; DOI: https://doi.org/10.34067/KID.0001192019
Mark Eijgelsheim
1Department of Nephrology, Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Ben Sprangers
2Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology, Rega Institute, Catholic University of Leuven, Leuven, Belgium; and
3Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
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Article Information

vol. 1 no. 3 158-161
DOI 
https://doi.org/10.34067/KID.0001192019

Published By 
American Society of Nephrology
Online ISSN 
2641-7650
History 
  • Published online March 26, 2020.

Article Versions

  • Earlier version (February 11, 2020 - 13:38).
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Copyright & Usage 
Copyright © 2020 by the American Society of Nephrology

Author Information

  1. Mark Eijgelsheim1, and
  2. Ben Sprangers2,3
  1. 1Department of Nephrology, Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
  2. 2Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology, Rega Institute, Catholic University of Leuven, Leuven, Belgium; and
  3. 3Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
  1. Correspondence:
    Dr. Ben Sprangers, Division of Nephrology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Email: ben.sprangers{at}uzleuven.be
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Kidney360: 1 (3)
Kidney360
Vol. 1, Issue 3
26 Mar 2020
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Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor–Associated Acute Kidney Injury: PRO
Mark Eijgelsheim, Ben Sprangers
Kidney360 Mar 2020, 1 (3) 158-161; DOI: 10.34067/KID.0001192019

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Kidney Biopsy Should Be Performed to Document the Cause of Immune Checkpoint Inhibitor–Associated Acute Kidney Injury: PRO
Mark Eijgelsheim, Ben Sprangers
Kidney360 Mar 2020, 1 (3) 158-161; DOI: 10.34067/KID.0001192019
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  • Article
    • Introduction
    • Cases
    • ATIN Is the Most Common IRAE but Also Other Kidney Adverse Events Occur in Patients on CPI Therapy
    • Not Performing a Biopsy Will Result in an Erroneous Diagnosis in a Significant Subset of Patients
    • Current Guidelines Do Not Value Kidney Biopsy Sufficiently
    • Histologic Diagnosis Is Necessary to Guide Treatment (or not)
    • CPI Retreatment in Patients with Previous Kidney IRAEs
    • Discussion of Cases
    • Conclusions
    • Disclosures
    • Author Contributions
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

  • PLEX in AAV- CON
  • PLEX for ANCA-vasculitis: PRO
  • Dialysis in HRS, PRO
Show more Debates in Nephrology

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Keywords

  • clinical nephrology
  • glomerular and tubulointerstitial diseases
  • checkpoint inhibitors
  • interstitial nephritis
  • kidney biopsy
  • onconephrology

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